Systems BiologybioRxivPreprint
Quantitative systems pharmacology modeling of pyrrolobenzodiazepine antibody-drug conjugates targeting BCMA
Inez Lam, David Dai, Rosalinda H. Arends…·Feilim Mac Gabhann
The paper develops a quantitative systems pharmacology model to analyze ADCs, showing that bystander effects are significant in vivo and highlighting key design parameters for optimizing efficacy and toxicity.