Rolf Erwin Brenner

p53-induced GDF-15 expression promotes a pro-regenerative response in human chondrocytes upon cartilage injury

This study identifies GDF-15 as a stress-responsive cytokine upregulated in PTOA, which promotes a pro-regenerative response in chondrocytes after cartilage injury.

Senolytic therapy combining Dasatinib and Quercetin restores the chondrogenic phenotype of human osteoarthritic chondrocytes by promoting the release of pro-anabolic mediators

Senolytic therapy with Dasatinib and Quercetin improves chondrocyte function in osteoarthritis by reducing senescence-associated secretory phenotype factors and increasing anabolic gene expression.