Michael J. McDonald

Trained phages constrain evolutionary routes to antibiotic resistance in Escherichia coli

This paper shows that trained phages can limit bacterial evolution to costly antibiotic resistance pathways by eliminating cost-free resistance routes.

Bayesian Parameter Balancing Enables Robust and Consistent Estimation of Kinetic Parameter Uncertainty

The paper introduces a Bayesian parameter balancing framework to estimate kinetic parameter uncertainty with robustness and consistency across studies.