Author

Colin M. Smith

UK Dementia Research InstituteORCID 0000-0002-5758-4698Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:differential expression· 1 Organism:human· 1 Assay:long-read sequencing· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Christopher A. JacksoniD· 1 shared Cláudio Gouveia RoqueiD· 1 shared Hemali P. PhatnaniiD· 1 shared Isobel Bolger· 1 shared Karthick NatarajaniD· 1 shared Kathryn O’NeilliD· 1 shared Molly HammelliD· 1 shared Oliver H. TamiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 36 mutual co-author links

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1 shared paperGenomics

Christopher A. JacksonORCID

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1 paper

Recent·Most cited

TDP-43 dysfunction leads to the accumulation of cryptic transposable element-derived exons, crypTEs, in iPSC derived neurons and ALS/FTD patient tissues

Isobel Bolger, Regina Shaw, Oliver H. Tam, Cláudio Gouveia Roque, Christopher A. Jackson, Kathryn O’Neill, Colin M. Smith, Hemali P. Phatnani, Karthick Natarajan, Molly Hammell

This study identifies TDP-43-dependent cryptic gene-TE fusions (crypTEs) in neurons and ALS/FTD tissues, showing their association with altered gene expression and potential pathogenic effects.

bioRxiv · Jan 9, 2026 · PreprintGenomics