Author

Lingjie Liu

Cold Spring Harbor LaboratoryORCID 0000-0002-5765-1213Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Adam C. SiepeliD· 2 shared Yixin ZhaoiD· 2 shared Rebecca Hassett· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

3 top collaborators · 3 mutual co-author links

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2 shared papersGenomics

Adam C. SiepelORCID

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2 papers

Recent·Most cited

GenomicsbioRxivPreprintDec 21, 2023

DNA-sequence and epigenomic determinants of local rates of transcription elongation

Lingjie Liu, Yixin Zhao, Adam C. Siepel

The paper investigates DNA-sequence and epigenomic factors influencing local transcription elongation rates.

2 citations

DNA methylationChIP-seq

𝕏 PostBluesky

GenomicsNucleic Acids ResearchPeer-reviewedSep 21, 2023

Model-based characterization of the equilibrium dynamics of transcription initiation and promoter-proximal pausing in human cells

Yixin Zhao, Lingjie Liu, Rebecca Hassett, Adam C. Siepel

The paper develops a probabilistic model to estimate transcription initiation and pause-escape rates from nascent RNA sequencing data, showing pause-escape is often more rate-limiting than previously thought.

12 citations

humanbulk RNA-seq

𝕏 PostBluesky