Immiscible proteins compete for RNA binding to order condensate layers
Wilton T. Snead, Mary K. Skillicorn, Krishna Shrinivas, Amy S. Gladfelter
The paper shows that core and shell proteins in paraspeckles compete for RNA binding, leading to layered condensate organization through immiscibility and competitive binding.
Proceedings of the National Academy of Sciences · Aug 6, 2025Peer-reviewedBiophysics