Epigenetically regulated p53 activity maintains intestinal regulatory T cell identity to prevent inflammation
Stephanie L. Silveria, Janneke G. C. Peeters, Jenna Vickery, Giovana M. B. Veronezi, Srinivas Ramachandran, Michel J.P. DuPage
This study shows that p53 activity, regulated epigenetically, maintains intestinal Treg identity and prevents inflammation by preventing Foxp3 loss in Th17 environments.
bioRxiv · Aug 29, 2025 · PreprintImmunology