Pain persists in mice lacking both Substance P and CGRPα signaling
Donald Iain MacDonald, Monessha Jayabalan, Jonathan T Seaman, Rakshita Balaji, Alec R. Nickolls, Alexander Theodore Chesler
This study shows that mice lacking both Substance P and CGRP signaling still exhibit normal pain responses, indicating these peptides are not essential for pain transmission.
eLife · Mar 7, 2025Peer-reviewedNeuroscience