Author
National Institutes of HealthORCID 0000-0002-4863-1093Unclaimed ORCID profile · follow to get notified of new preprints
Mutual co-authors in cluster
4 papers
Recent·Most cited
Donald Iain MacDonald, Rakshita Balaji, Alexander Theodore Chesler
The paper shows that nociceptors use both glutamate and neuropeptides to transmit pain signals, with redundancy in their signaling pathways.
bioRxiv · Sep 9, 2025 · PreprintNeuroscience
Donald Iain MacDonald, Monessha Jayabalan, Jonathan T Seaman, Rakshita Balaji, Alec R. Nickolls, Alexander Theodore Chesler
This study shows that mice lacking both Substance P and CGRP signaling still exhibit normal pain responses, indicating these peptides are not essential for pain transmission.
eLife · Mar 7, 2025Peer-reviewedNeuroscience
Donald Iain MacDonald, Shafaq Sikandar, Jan Weiss, Martina M. Pyrski, Ana Paula Luiz, Queensta Millet, Edward C. Emery, Flavia Mancini, Gian Domenico Iannetti, Sascha R.A. Alles, Jing Zhao, James J. Cox, Robert M. Brownstone, Frank Zufall, John N. Wood
This study identifies opioid-dependent inhibition of neurotransmitter release as the primary mechanism of analgesia in NaV1.7 null mutants in mice and humans.
bioRxiv · Jun 1, 2020 · PreprintNeuroscience
Donald Iain MacDonald, Ana Paula Luiz, Queensta Millet, Edward C. Emery, John N. Wood
The paper identifies silent cold-sensing neurons that become active in neuropathic pain and contribute to cold allodynia through peripheral sensitization.
bioRxiv · May 2, 2020 · PreprintNeuroscience