Author

Frédéric Paquin-Lefebvre

École Normale Supérieure - PSLORCID 0000-0002-5840-5049Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Assay:electrophysiology· 1 Approach:experimental assay· 1 Assay:imaging· 1 Approach:statistical model· 1 Research Focus:synaptic & neural circuits· 1

Frequent Co-Authors

David HolcmaniD· 1 shared Eduard KorkotianiD· 1 shared Jürgen ReingruberiD· 1 shared Liliia KushnirevaiD· 1 shared Nathalie RouachiD· 1 shared Samuel Kubler· 1 shared Simon B. LaughliniD· 1 shared Tatiana FeofilaktovaiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 28 mutual co-author links

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1 shared paperNeuroscience

David HolcmanORCID

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2 papers

Recent·Most cited

Electrodiffusion analysis of concentration and voltage changes in thin cylindrical domains using cross-diffusion modelling

Frédéric Paquin-Lefebvre, Jürgen Reingruber

This paper derives analytic current-voltage-concentration relations for narrow cylindrical domains using cross-diffusion equations, showing how ion influx affects voltage and other ions' concentrations.

bioRxiv · May 15, 2026 · PreprintBiophysics

Synaptic Input Triggers On-Demand Spine-Specific Mitochondrial ATP Production and Delivery

Frédéric Paquin-Lefebvre, Liliia Kushnireva, Zelai Xu, Samuel Kubler, Tatiana Feofilaktova, Simon B. Laughlin, Nathalie Rouach, Eduard Korkotian, David Holcman

The paper shows synaptic input triggers on-demand mitochondrial ATP production and delivery in spines with a spine apparatus, optimized by geometry and calcium signaling.

bioRxiv · Mar 11, 2026 · PreprintNeuroscience