Nathalie Rouach

DETECT improves detection of low-salience fluorescence events by combining background suppression, classification, and tracking, enabling analysis of neuromodulatory activity.

The paper identifies rhythmic bursting in a subset of VLPO neurons, showing it is intrinsic and may contribute to sleep regulation.

The paper studies short-term plasticity (STP) in the retinocollicular pathway of mice, revealing three distinct stages of STP involving both synaptic and nonsynaptic mechanisms.

The paper shows synaptic input triggers on-demand mitochondrial ATP production and delivery in spines with a spine apparatus, optimized by geometry and calcium signaling.

The paper identifies specialized astrocyte subtypes in the VLPO, including long-projection astrocytes with hominid-like morphology, revealing enhanced glial network integration in a sleep-promoting nucleus.

This paper uses in vivo recordings and a neural mass model to show how thalamocortical excitatory-inhibitory dynamics generate α-wave patterns during anesthesia, linking EEG oscillations to network dynamics.

The paper shows that astrocytes regulate maternal behavior through connexin 30, affecting oxytocin levels and synaptic structure in the hypothalamus of female mice.

The paper investigates GBM cell spreading in mouse and human brain tissue, identifying Cx43 upregulation as a key factor in tumor infiltration.

This study shows that enhancing astrocytic Kir4.1 function reduces spasticity in SCI mice by improving K+ uptake and preventing neuronal hyperexcitability.

The paper introduces AstroNet, a graph reconstruction algorithm that maps functional connectivity in astrocytic networks using two-photon calcium imaging, revealing region-specific connectivity patterns in the hippocampus and motor cortex.

This study shows that astroglial Ophn1 deficiency impairs synaptic transmission and behavior, with potential therapeutic targeting of the RhoA/ROCK pathway.

The paper shows that oxytocin-induced astrocyte process retraction in the amygdala modulates freezing behavior during stress by enhancing neuronal sensitivity to potassium.

The paper shows astroglial gap junctions enhance hippocampal network activity by maintaining afterhyperpolarization through KCNQ channels, independent of glutamate or metabolic factors.

The paper measures short-term plasticity in synaptic inputs and spike transmission at the retinocollicular synapse in mice, finding that spike transmission shows greater facilitation than dendritic responses and is influenced by the timing of the last postsynaptic spike.

The paper investigates region-specific properties of astrocytes in the visual layer of the superior colliculus, finding they have higher density, complex morphology, and closer proximity to synapses compared to astrocytes in other brain regions.

This study identifies RACK1 as a repressor of KIR4.1 translation in astrocytes, showing its role in regulating neuronal activity through modulation of KIR4.1 expression.

This study identifies astrocytic Kir4.1 channels as critical for neuronal rhythmicity in the spinal CPG, showing their role in regulating locomotion through K+ clearance.

The paper shows dendritic spines refill ER calcium stores through controlled calcium entry without depletion, using computational modeling and imaging.

This study shows that oxytocin acts on astrocytes in the central amygdala to promote a positive emotional state, challenging the notion that oxytocin only affects neurons.

The paper shows astroglial glutamine supply is essential for synaptic activity and memory via connexin43-mediated transport.

This study identifies astrocytes as key regulators of critical period closure in the mouse visual cortex through connexin 30-mediated inhibition of MMP9.

The paper identifies a unique molecular repertoire in hippocampal perisynaptic astrocytic processes, regulated by local translation during fear conditioning.

The paper reviews a tri-compartment model of potassium dynamics between neurons, astrocytes, and the extracellular space, showing how astrocytes buffer potassium and how channel disruptions affect neuronal activity.