Spliceosomal mutations decouple 3' splice site fidelity from cellular fitness
Kevin R. Roy, Jason Gabunilas, Dean Neutel, Michelle Ai, Zoe Yeh, Joyce Samson, Guochang Lyu, Guillaume Chanfreau
This study shows that inactivating Prp18p leads to global activation of alternative 3' splice sites with divergent sequences, without affecting cellular fitness.
Nucleic Acids Research · Oct 25, 2023Peer-reviewedMolecular Biology