Guillaume Chanfreau

The paper investigates the role of RES complex subunits Snu17p and Bud13p in splicing efficiency in budding yeast, finding they buffer against weak splicing signals and are critical for inefficient intron splicing.

The paper shows that the m6A writer spares canonical 3' splice sites from methylation, allowing efficient splicing despite cotranscriptional methylation.

This study uses a Drosophila model to show that RNA exosome mutations disrupt brain transcriptomes and cause neurodegeneration by altering rRNA processing.

The paper shows that transcription termination defects in yeast lead to splicing inefficiency and errors, highlighting its importance for splicing fidelity in compact genomes.

This study investigates the role of zinc finger domains in the yeast splicing factor Luc7 using humanized variants, revealing their impact on splice site selection and interactions with Prp28.

This study shows that inactivating Prp18p leads to global activation of alternative 3' splice sites with divergent sequences, without affecting cellular fitness.

NanoBlot visualizes RNA isoform usage from third-generation sequencing data by generating Northern blot and RT-PCR-like images, offering customization and multiplexing capabilities.

The paper shows that splicing inactivation leads to hybrid mRNA-snoRNA transcripts that are degraded by cytoplasmic decay, highlighting splicing's role in snoRNA biogenesis.