Rational design of hidden thermodynamic driving through DNA mismatch repair
Natalie Haley, Thomas E. Ouldridge, Alessandro Geraldini, Ard A. Louis, Jonathan Bath, Andrew J. Turberfield
The paper introduces a method to enhance thermodynamic drive in DNA strand displacement reactions by strategically placing mismatches, without significantly affecting forward reaction rates.
bioRxiv · Sep 25, 2018 · PreprintSynthetic Biology