This paper develops DNA origami caps to selectively functionalize microtubule tips and lattice defects, enabling controlled cargo capture and dynamic visualization.

bioRxiv · May 11, 2026 · PreprintBioengineering

Controlling DNA-RNA strand displacement kinetics with base distribution

Eryk J. Ratajczyk, Jonathan Bath, Petr Šulc, Jonathan P. K. Doye, Ard A. Louis, Andrew J. Turberfield

This study shows that base distribution along an invading strand strongly affects DNA-RNA strand displacement kinetics, enabling design of sequences with reaction rates spanning two orders of magnitude.

Proceedings of the National Academy of Sciences · Jun 6, 2025Peer-reviewedBiophysics

Tissue-specific modulation of CRISPR activity by miRNA-sensing guide RNAs

Antonio Garcia-Guerra, Chaitra Sathyaprakash, Olivier G. de Jong, Wooi Fang Lim, Pieter Vader, Samir EL Andaloussi, Jonathan Bath, Jesús Reiné, Yoshitsugu Aoki, Andrew J. Turberfield, Matthew J. A. Wood, Carlo Rinaldi

This paper introduces CRISPR MiRAGE, a miRNA-sensing guide RNA system that enables tissue-specific gene editing by modulating CRISPR activity based on miRNA signatures.

Nucleic Acids Research · Jan 8, 2025Peer-reviewedBioengineering

Rational design of hidden thermodynamic driving through DNA mismatch repair

Natalie Haley, Thomas E. Ouldridge, Alessandro Geraldini, Ard A. Louis, Jonathan Bath, Andrew J. Turberfield

The paper introduces a method to enhance thermodynamic drive in DNA strand displacement reactions by strategically placing mismatches, without significantly affecting forward reaction rates.

bioRxiv · Sep 25, 2018 · PreprintSynthetic Biology