A Comprehensive Proteogenomic and Spatial Analysis of Innate and Acquired Resistance of Metastatic Melanoma to Immune Checkpoint Blockade Therapies
S N Wei, Kuang Du, Hongbin Lan, Zhenyu Yang, Yulan Deng, Zhi Wei, Dennie Tompers Frederick, Jin‐Ho Lee, Marilyne Labrie, Tian Tian, Tabea O. C. Moll, Yeqing Chen, Ryan Joseph Sullivan, Gordon Brent Mills, Genevieve Marie Boland, , Gao Zhang
This study identifies molecular mechanisms of resistance to immune checkpoint blockade in metastatic melanoma using proteogenomic and spatial analyses of tumor and immune microenvironment data.
bioRxiv · Sep 12, 2024 · PreprintGenetics