Dennie Tompers Frederick

The paper identifies combinatorial KRAS/FGFR dependence in pancreatic cancer through genetic interaction mapping and shows that combined inhibition overcomes resistance.

The paper identifies a mature dendritic cell subtype associated with improved immune response and prognosis in melanoma patients treated with anti-PD-1 checkpoint inhibitors.

The paper identifies biparatopic antibodies targeting FGFR2 extracellular domain that effectively block FGFR2 fusion-driven cholangiocarcinoma signaling and growth.

This study identifies molecular mechanisms of resistance to immune checkpoint blockade in metastatic melanoma using proteogenomic and spatial analyses of tumor and immune microenvironment data.

This paper introduces MRD-EDGE, a machine learning platform for ultrasensitive ctDNA detection in plasma WGS, showing improved sensitivity and broader applicability for MRD monitoring.

This study applies low-cost whole genome sequencing to detect circulating tumor DNA at high sensitivity in plasma samples, achieving error rates as low as 10^-7 and enabling cancer monitoring without matched tumor sequencing.

The paper develops DNA- and RNA-based models combining immune and tumor features to predict outcomes of checkpoint inhibition in melanoma.