Author

John Hoffer

Harvard UniversityORCID 0000-0002-5877-4266Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Assay:imaging· 1

Frequent Co-Authors

Jeremy L. MuhlichiD· 2 shared Peter Karl SorgeriD· 2 shared Adam NelsoniD· 1 shared Adrienne Gropper WaksiD· 1 shared Alexander P. GottliebiD· 1 shared Andréanne GagnéiD· 1 shared Carlos Wagner S WanderleyiD· 1 shared Daniel E. MichaudiD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersCancer Biology

Jeremy L. MuhlichORCID

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2 papers

Recent·Most cited

An estrogen receptor signaling transcriptional program linked to immune evasion in human hormone receptor-positive breast cancer

Kenichi Shimada, Daniel E. Michaud, Yvonne Xiaoyong Cui, Kelly Zheng, Jonathan L. Goldberg, Zhenlin Ju, Stuart J. Schnitt, Ricardo Pastorello, Lukas D. Kania, John Hoffer, Jeremy L. Muhlich, Nhan Hyun, Robert Krueger, Alexander P. Gottlieb, Adam Nelson, , Jennifer L. Guerriero

This study identifies an estrogen receptor signaling program in HR+ breast cancer that suppresses immune responses by reducing T cell infiltration and HLA expression, suggesting therapeutic targets to enhance immunogenicity.

bioRxiv · Nov 23, 2024 · PreprintCancer Biology

Integrating spatial profiles and cancer genomics to identify immune-infiltrated mismatch repair proficient colorectal cancers

Jeremiah A. Wala, Ino de Bruijn, Shannon Coy, Andréanne Gagné, Sabrina Chan, Yu‐An Chen, John Hoffer, Jeremy L. Muhlich, Nikolaus D. Schultz, Sandro Santagata, Peter Karl Sorger

The paper identifies a subset of mismatch repair proficient colorectal cancers with high immune infiltration that may benefit from immune checkpoint inhibitors, using spatial profiling and genomics.

bioRxiv · Sep 24, 2024 · PreprintCancer Biology