Author

Stuart J. Schnitt

Brigham and Women's HospitalORCID 0000-0002-3608-7828Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:spatial domain detection· 3 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:statistical model· 2

Frequent Co-Authors

Adam NelsoniD· 3 shared Jennifer L. GuerrieroiD· 3 shared Kenichi ShimadaiD· 3 shared Adrienne Gropper WaksiD· 2 shared Carlos Wagner S WanderleyiD· 2 shared Daniel E. MichaudiD· 2 shared Elizabeth Ann MittendorfiD· 2 shared Sara M. TolaneyiD· 2 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCancer Biology

Adam NelsonORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

TALAVE in Breast Cancer: BRCA1/2 Mutation-Dependent Immune Remodeling after PARP Inhibition with Limited Checkpoint Engagement

Filipa C. Lynce, Kaoru Shimada, Claudine J. Isaacs, Xue Geng, Edward T. Richardson, Adam Nelson, Candace Bavette Mainor, Mei Wei, Julie Marie Collins, Paula Raffin Pohlmann, Arielle Lutterman Heeke, Kelly F Zheng, Madeline G Townsend, Nicole Swanson, Lauren M. Sloat, , Jennifer L. Guerriero

The paper shows BRCA-mutant breast cancers respond to PARP inhibitors with immune remodeling, but PD-L1 blockade is ineffective due to spatial separation of PD-L1+ cells and PD-1+ T cells.

bioRxiv · Sep 18, 2026 · PreprintCancer Biology

APOE Tumor-Associated Macrophages and CD4-DOCK4 T Cells Reveal Distinct Microenvironmental Features in HER2-Low and HER2-0 Hormone Receptor-Positive Breast Cancer

Carlos Wagner S Wanderley, Daniel E. Michaud, Kenichi Shimada, Adam Nelson, Jingxin Fu, Stuart J. Schnitt, Sara M. Tolaney, Elizabeth Ann Mittendorf, Romualdo Barroso‐Sousa, Adrienne Gropper Waks, Paolo Tarantino, Jennifer L. Guerriero

The paper identifies distinct immune and stromal features in HR+ HER2-low and HER2-0 breast cancers using molecular and multiplexed imaging.

bioRxiv · Sep 4, 2025 · PreprintCancer Biology

An estrogen receptor signaling transcriptional program linked to immune evasion in human hormone receptor-positive breast cancer

Kenichi Shimada, Daniel E. Michaud, Yvonne Xiaoyong Cui, Kelly Zheng, Jonathan L. Goldberg, Zhenlin Ju, Stuart J. Schnitt, Ricardo Pastorello, Lukas D. Kania, John Hoffer, Jeremy L. Muhlich, Nhan Hyun, Robert Krueger, Alexander P. Gottlieb, Adam Nelson, , Jennifer L. Guerriero

This study identifies an estrogen receptor signaling program in HR+ breast cancer that suppresses immune responses by reducing T cell infiltration and HLA expression, suggesting therapeutic targets to enhance immunogenicity.

bioRxiv · Nov 23, 2024 · PreprintCancer Biology