An estrogen receptor signaling transcriptional program linked to immune evasion in human hormone receptor-positive breast cancer
Kenichi Shimada, Daniel E. Michaud, Yvonne Xiaoyong Cui, Kelly Zheng, Jonathan L. Goldberg, Zhenlin Ju, Stuart J. Schnitt, Ricardo Pastorello, Lukas D. Kania, John Hoffer, Jeremy L. Muhlich, Nhan Hyun, Robert Krueger, Alexander P. Gottlieb, Adam Nelson, , Jennifer L. Guerriero
This study identifies an estrogen receptor signaling program in HR+ breast cancer that suppresses immune responses by reducing T cell infiltration and HLA expression, suggesting therapeutic targets to enhance immunogenicity.
bioRxiv · Nov 23, 2024 · PreprintCancer Biology