Enhanced prediction of breast cancer patient response to chemotherapy by integrating deconvolved expression patterns of immune, stromal and tumor cells
Saugato Rahman Dhruba, Sahil Sahni, Binbin Wang, Di Wu, Padma Sheila Rajagopal, Yael Gurevich, Eldad David Shulman, Sanju Sinha, Stephen‐John Sammut, Carlos Caldas, Kun Wang, Eytan Ruppin
This paper develops DECODEM to predict chemotherapy response by integrating deconvolved expression patterns of immune, stromal, and tumor cells in breast cancer, finding that cell-type-specific expression is predictive of response.
Cancer Letters · Oct 30, 2025Peer-reviewedBioinformatics