Shao Thing Teoh

The paper identifies a stable metabolic-secretory defect in RA monocytes across activation states using multi-omics analysis, linking reduced glycosylation to disease mechanisms.

The paper maps protein-protein interactions of 396 SLC transporters using interaction proteomics and functional assays, providing a resource for understanding SLC function and drug targeting.

The paper systematically identifies genetic interactions among human solute carrier proteins using CRISPR-Cas12a and -Cas9, revealing 1,236 interactions with growth phenotypes and highlighting SLC39A1's role in metabolic reprogramming.

The paper systematically evaluates the metabolic and transcriptional effects of SLC superfamily members, identifying new substrates and functional groups.

The paper creates a functional landscape of human solute carriers by integrating multi-omics data and curated knowledge, assigning functions to each SLC and providing a web-accessible resource.