Fabian Frommelt

The paper analyzes physicochemical features of transmembrane protein-protein interfaces to determine their topology, finding that amino acid composition and secondary structure are key predictors.

This study shows that SERDs induce ER SUMOylation, which recruits co-repressors to suppress transcription, rather than relying on ER degradation for their activity.

This study identifies ARID5B as a chromatin repressor that interacts with HDAC1/2 to repress B cell-specific genes, linking its germline variants to B-ALL risk.

The paper identifies inhibitor-induced kinase destabilization as a common phenomenon and reveals that it occurs through endogenous proteolytic mechanisms rather than classical ubiquitination.

The paper maps protein-protein interactions of 396 SLC transporters using interaction proteomics and functional assays, providing a resource for understanding SLC function and drug targeting.

The paper systematically identifies genetic interactions among human solute carrier proteins using CRISPR-Cas12a and -Cas9, revealing 1,236 interactions with growth phenotypes and highlighting SLC39A1's role in metabolic reprogramming.

The paper systematically evaluates the metabolic and transcriptional effects of SLC superfamily members, identifying new substrates and functional groups.

The paper creates a functional landscape of human solute carriers by integrating multi-omics data and curated knowledge, assigning functions to each SLC and providing a web-accessible resource.

The paper constructs a tissue-specific protein interaction atlas using proteomic data from 11 human tissues, identifying key drivers of inter-tissue variation and prioritizing disease genes in brain disorders.

DIP-MS resolves protein complex isoforms using deep learning and mass spectrometry, revealing new subunits in human prefoldin complexes.

The paper performs a genome-wide CRISPR/Cas9 knock-out screen to identify genes involved in phagocytosis, validates key complexes, and maps their functional roles in human cells.

The paper develops an experimental strategy to link phosphorylation events with protein complex formation, revealing PTPN14's role in regulating YAP1's interaction with LATS1/2 kinases.

The paper presents a rapid workflow combining experimental and computational methods to profile protein complex re-organization in cellular states, showing distinct changes during differentiation and macrophage stimulation.

The paper introduces PCprophet, a computational framework for identifying and analyzing protein complexes from co-fractionation mass spectrometry data across conditions.

The paper quantifies proteome assembly state changes during mitosis using SEC-SWATH-MS and identifies new mitotic complex disassembly events.