Charlie Hatcher

Application of bidirectional Mendelian randomization to assess the relationship between the gut microbiome and esophageal cancer

This study uses bidirectional Mendelian randomization to examine the causal relationship between the gut microbiome and esophageal cancer, finding potential bidirectional effects but cautioning against overinterpretation due to biases.

Evidence of positive and negative selection associated with DNA methylation

The paper estimates selection coefficients for DNA methylation sites and finds evidence of both positive and negative selection, highlighting DNAm's role in biological pathways.

Leveraging brain cortex-derived molecular data to elucidate epigenetic and transcriptomic drivers of neurological function and disease

The paper identifies genetic variants influencing both molecular phenotypes and neurological traits using Bayesian colocalization analysis across brain cortex data.