Caroline Laura Relton

This study investigates how DNA methylation (DNAm) links racial discrimination, economic adversity, and air pollution to health inequities using epigenome-wide association analyses.

This study identifies cell type-specific DNA methylation associations with childhood ADHD symptoms using deconvolution and sequencing-based methylation data from peripheral and cord blood.

This study identifies DNA methylation at the SOCS3 gene as a factor influencing child height in low and middle-income countries, with a causal effect confirmed by Mendelian randomization.

The paper identifies genetic impacts on DNA methylation across 724,499 CpGs in blood samples, revealing co-localisations with disease traits and regulatory mechanisms.

This study evaluates the reliability of DNA methylation measurements using the Illumina Infinium MethylationEPIC BeadChip at low DNA input levels, finding that 40ng DNA can be used with quality checks.

The paper investigates how childhood adversity during sensitive periods affects DNA methylation in genes regulating developmental plasticity using a gene set-based approach.

This study identifies epigenetic markers associated with night shift work, showing links to BMI, education, smoking, and accelerated biological aging.

This study examines DNA methylation at birth and its association with childhood cognitive skills, finding weak single CpG site associations and one region near DUSP22 linked to non-verbal cognition.

This study maps DNA methylation changes across the human life course using data from 7,037 individuals, showing increased variability and age-related mean changes at specific CpG sites.

This study examines how time-varying childhood adversity affects DNA methylation across development, finding persistent effects at age 15 and resolving differences by adolescence.

This study identifies DNA methylation sites associated with coffee and tea consumption using EWAS, finding potential links to fatty liver disease through PHGDH expression.

This study uses Mendelian randomization and colocalization to identify 12 genes, three novel, associated with glioma risk across tissues and subtypes.

The paper analyzes DNA methylation changes across birth to late adolescence in two cohorts, finding widespread nonlinear changes and sex-specific patterns.

This study identifies DNA methylation sites at birth associated with ADHD symptoms later in childhood, but finds no such associations at school age.

This study investigates the association between breastfeeding and DNA methylation changes in children and adolescents using data from the ALSPAC cohort, finding some consistent methylation sites linked to breastfeeding at ages 7 and 15-17.

This paper identifies DNA methylation sites associated with aggression through a meta-analysis of epigenome-wide studies across different age groups and tissues.

This paper examines DNA methylation's association with BMI across different life stages, finding it explains limited BMI variance and is not a strong predictor of future BMI.

This study investigates whether genetic liability to non-syndromic cleft lip/palate influences educational attainment and intelligence, finding little evidence of shared genetic causation.

This paper compares Bayesian network analysis with Mendelian randomization for causal inference in complex datasets, finding BN with genetic anchors performs better in certain scenarios.

This study uses Mendelian randomization to investigate causal relationships between smoking-associated DNA methylation and lung function, identifying 18 CpGs with potential causal effects on FEV1.

This study uses transcriptome-wide Mendelian randomization to identify tissue-dependent gene-trait associations across 48 tissues and 395 traits, revealing genetic colocalization and potential drug repositioning opportunities.

The paper identifies genetic links between impaired pulmonary function and increased lung cancer risk, showing causal relationships through Mendelian randomization and highlighting immune-related pathways.

This study identifies genetic effects on birth weight and their impact on cardio-metabolic traits, distinguishing fetal and maternal contributions.

The paper identifies genetic variants influencing both molecular phenotypes and neurological traits using Bayesian colocalization analysis across brain cortex data.

The paper identifies tissue-specific genetic loci influencing cardiovascular disease risk by integrating gene expression, Mendelian randomization, and colocalization analyses.

This study identifies 40 CpG sites with differential methylation at age 7 linked to adversity exposure timing, showing infancy as a sensitive period for DNAm changes.

The paper identifies three loci where genetic liability to non-syndromic cleft lip/palate may be mediated by DNA methylation variation in blood and tissue.

This study evaluates the causal relationship between DNA methylation and CRP using Mendelian randomization and finds potential causal effects of DNA methylation on CRP levels at three CpG sites.

The paper investigates whether DNA methylation mediates genetic risk for type 1 diabetes by analyzing SNP-methylation associations across different life stages.

The paper examines how childhood adversity exposure affects epigenetic aging using DNA methylation clocks in children, finding that timing and type of adversity exposure significantly influence biological age.