Josine L. Min

The paper identifies age-dependent methylation quantitative trait loci (longitudinal mQTLs) across the lifespan using blood DNAm data from two cohorts, finding consistent genotype-by-age effects and associations with multiple phenotypes.

The paper identifies vmeQTLs for blood DNA methylation variance in MZ twins, showing gene-environment interactions and cell-type effects relevant to immune disease.

This study identifies 440 genes/proteins associated with atopic dermatitis severity through multi-omics analyses and highlights four with significant cross-evidence, including CEP85, which may contribute to severity via impaired phagocytosis.

This study uses twin-based Mendelian randomisation to find bidirectional causation between smoking and blood DNA methylation at multiple genomic sites.

The paper shows that imputing DNA methylation loci from epigenome-wide data provides stronger associations with smoking and age than directly measured CpGs.

This study identifies genetic links between early vocabulary development and ADHD and cognition traits using genome-wide analyses.

The paper investigates the stability and regulatory implications of DNA co-methylation across age and ancestry, finding stable patterns and links to transcription factor binding and chromatin interactions.

The paper estimates selection coefficients for DNA methylation sites and finds evidence of both positive and negative selection, highlighting DNAm's role in biological pathways.

The paper identifies genetic variants influencing DNA methylation in blood and shows their associations with complex traits and diseases, but finds limited direct causality.

This paper prioritises candidate causal genes at 25 atopic dermatitis GWAS loci using a novel pipeline called ADGAPP, identifying both known and novel candidates.

This study investigates DNA methylation as a mediator between pigmentation genes, traits, and skin cancer using GWAS and epigenetic data from European populations.

This study identifies 137 genome-wide significant loci associated with DNA methylation biomarkers of ageing using DNAm and SNP data from over 41,000 individuals.

The paper identifies 9 novel genetic loci, including low-frequency variants in TP53, associated with head circumference and intracranial volume in up to 46,000 individuals.

Meffil normalizes and analyzes large DNA methylation datasets, reducing memory usage and technical variation while improving EWAS power.

This paper estimates narrow-sense heritability using identity-by-descent information in unrelated individuals and finds that IBD-based methods can capture rare variant contributions but are affected by stratification.

The paper introduces a method to assess enrichment of GWAS loci in regulatory regions, identifying novel biological insights across 27 traits.