Valeria Difilippo

SarcDBase is a tool that extracts and interprets genetic alterations from tumor sequencing data, showing high agreement with curated diagnoses in most cases.

This study identifies four subgroups of osteosarcomas based on genomic and transcriptomic analysis, revealing distinct mechanisms of CDK4 amplification in relation to MDM2 or TP53 alterations.

CRAFT predicts circRNA functions by analyzing sequence interactions with miRNAs and RBPs, coding potential, and integrates predictions to infer regulatory networks.