Spread of pathological human Tau from neurons to oligodendrocytes and loss of high-firing pyramidal neurons in ageing mice
Tim J. Viney, Barbara Sárkány, A. Tugrul Ozdemir, Katja Hartwich, Judith V. Schweimer, David M. Bannerman, Péter Somogyi
This study investigates how human pTau affects hippocampal neurons and network activity in tauopathy model mice, finding pTau accumulation in pyramidal neurons and spread to oligodendrocytes, with preserved neuronal coordination despite neurodegeneration.
Cell Reports · Nov 1, 2022Peer-reviewedNeuroscience