Tim J. Viney

This study shows that pathological tau expression in the anterodorsal thalamic nucleus disrupts head direction signaling, leading to spatial disorientation in mice.

The paper identifies distinct subtypes of head direction cells in the mouse anterodorsal thalamus based on their response profiles and connectivity patterns.

The paper introduces an in situ seeding immunodetection assay to visualize alpha-synuclein and tau seeding activities with high spatial resolution in intact tissues, revealing neuron-driven alpha-synuclein seeding in Parkinson's disease before clinical symptoms.

This study identifies the synaptic targets and cellular sources of CB1 and VGLUT3-expressing nerve terminals in the human cerebral cortex, showing their interactions with GABAergic neurons.

The paper identifies early and selective subcortical Tau pathology in the Papez circuit, particularly in the anterodorsal thalamic nucleus, and links it to disorientation in dementia.

This study investigates how human pTau affects hippocampal neurons and network activity in tauopathy model mice, finding pTau accumulation in pyramidal neurons and spread to oligodendrocytes, with preserved neuronal coordination despite neurodegeneration.