Cancer BiologybioRxivPreprint
Identification of a lineage-agnostic splicing signature caused by PRMT5 inhibition
Matthew R. Tonini, Samuel R. Meier, Shangtao Liu…·Kimberly J. Briggs
This paper identifies a splicing signature caused by PRMT5 inhibition in MTAP-deleted cancers, showing histology-agnostic splicing changes and potential as a biomarker for PRMT5 inhibitor activity.
DOI 10.64898/2026.03.26.714409