Luisa Cimmino

This paper identifies a splicing signature caused by PRMT5 inhibition in MTAP-deleted cancers, showing histology-agnostic splicing changes and potential as a biomarker for PRMT5 inhibitor activity.

This study shows that B12 supplementation promotes gut dysbiosis and inflammation, which enhances myelopoiesis in Tet2-deficient mice, suggesting a microbiome-mediated mechanism for clonal hematopoiesis.

This study shows that H3K36M mutations in HNSCC create a therapeutic window by altering H3K27me3 levels, making tumors sensitive to PARP1/2 inhibitors or their combination with H3K27me3-upregulating agents.