Rewired NAD+ metabolism promotes NF-κB-mediated oxidative stress and disrupts lipid homeostasis in liver fibrosis progression
Hiu‐Lok Ngan, Jacinth Wing‐Sum Cheu, Kenneth Kin‐Leung Kwan, Carmen Chak‐Lui Wong, Hong Yuan Yan, Zongwei Cai
This study identifies NAD+ metabolism rewiring as a key driver of oxidative stress and lipid dysregulation in liver fibrosis progression using multi-omics analyses in a mouse model.
bioRxiv · Aug 6, 2025 · PreprintSystems Biology