Non-canonical ORFs are an important source of tumor-specific antigens in a liver cancer meta-cohort
Marta E. Camarena, Patrick Theunissen, Marta Ruiz, Jorge Ruiz‐Orera, Beatriz Calvo-Serra, Robert Castelo, Pablo Sarobe, Puri Fortes, Júlia Perera‐Bel, M. Mar Albà
The paper identifies non-canonical ORFs as a significant source of tumor-specific antigens in liver cancer, showing they can trigger immune responses and are shared among a substantial proportion of patients.
bioRxiv · Oct 30, 2023 · PreprintGenomics