Author

Joshua W. Thompson

University of Illinois ChicagoORCID 0000-0002-6010-0236Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

Abhalaxmi SinghiD· 1 shared Asrar B. MalikiD· 1 shared Chinnaswamy TiruppathìiD· 1 shared Mohammad AnasiD· 1 shared Nithish Raj PrasadiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 10 mutual co-author links

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1 shared paperImmunology

Abhalaxmi SinghORCID

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1 paper

Recent·Most cited

E3 ubiquitin ligase SYVN1 mediates K63-linked ubiquitination of DDX3X to activate Macrophage NLRP3 Inflammasome

Mohammad Anas, Abhalaxmi Singh, Nithish Raj Prasad, Joshua W. Thompson, Chinnaswamy Tiruppathì, Asrar B. Malik

This study identifies SYVN1 as an upstream regulator of DDX3X, showing that SYVN1-mediated K63 ubiquitination of DDX3X activates the NLRP3 inflammasome and stress granule formation.

bioRxiv · Sep 20, 2026 · PreprintImmunology