Asrar B. Malik

E3 ubiquitin ligase SYVN1 mediates K63-linked ubiquitination of DDX3X to activate Macrophage NLRP3 Inflammasome

This study identifies SYVN1 as an upstream regulator of DDX3X, showing that SYVN1-mediated K63 ubiquitination of DDX3X activates the NLRP3 inflammasome and stress granule formation.

Ubiquitin ligase CHFR impairs Tie2 signaling via K48-linked ubiquitylation and degradation of Akt1 in endothelial cells

This study identifies CHFR as a regulator of endothelial inflammatory responses by promoting Akt1 ubiquitylation and degradation, thereby impairing Tie2 signaling and endothelial barrier integrity.

Innate Immune Function of Neutrophil Cytoplasts Generated Post-Vital NETosis

This study identifies PMNcyto as a functional cell type generated post-vital NETosis that actively kills bacteria and reduces pneumonia-induced mortality.

CaMKKβ regulates transcription factor Elf2 gene methylation to maintain endothelial junctional barrier integrity

This study shows that CaMKKβ regulates Elf2 gene methylation, which is essential for maintaining endothelial barrier integrity by controlling Tie2 and VE-cadherin expression.

Tolerance to Lung Infection in TWIK2 K+ Efflux Mediated Macrophage Trained Immunity

This paper identifies ATP-mediated TWIK2 channel activation in alveolar macrophages as a mechanism for trained immunity and enhanced microbial killing.

Tissue Regeneration Requires Edema Fluid Clearance by Compensatory Lymphangiogenesis in Zebrafish

This study shows that lymphangiogenesis is crucial for tissue regeneration and edema clearance in zebrafish, revealing key genes and mechanisms involved in this process.