MicrobiologymBioPeer-reviewed
The African Swine Fever Virus gene MGF_360-4L inhibits interferon signaling by recruiting mitochondrial selective autophagy receptor SQSTM1 degrading MDA5 antagonizing innate immune responses
Hualin Sun, Jifei Yang, Zhonghui Zhang…·Qingli Niu
This study identifies ASFV MGF_360-4L as a virulence gene that inhibits interferon signaling by degrading MDA5 via SQSTM1-mediated autophagy and blocking ISGylation, leading to reduced viral virulence in pigs.
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