Chenli Liu

This paper shows that DNA replication initiation in E. coli sets a fixed mass increment for cell division, resolving conflicting models of division timing.

This paper introduces OPENER, an engineered eRF1 variant that suppresses nonsense mutations and enables nonstandard amino acid incorporation, showing therapeutic benefits in a Duchenne muscular dystrophy model.

This study links DnaA activity oscillations to DNA replication initiation in E. coli, showing they persist independently of dnaA expression and proposing an extrusion model for regulation.

The paper shows that combining specific microbes with phage treatment improves pathogen exclusion in shrimp, highlighting the synergy between phage predation and microbial competition.

The paper shows that increased bacterial motility during range expansion reduces phage spread by spatially sorting infected and uninfected cells, leading to migratory culling of viruses.

This paper introduces a method to enhance membrane protein synthesis in synthetic cells by recruiting mRNA to phospholipid membranes using cholesterol-modified DNA.

This study identifies Cancer Driving Nucleotides (CDNs) across cancer types and patients, finding that most remain unidentified and highlights the need for larger sample sizes to improve detection.

This study develops a theory to identify Cancer Driving Nucleotides (CDNs) by analyzing mutation recurrence across large cancer datasets, finding that mutations recurring at least three times are likely CDNs.

This study shows SRSF2 is essential for mRNA splicing and spermatogenesis, with its deletion causing infertility and disrupting key developmental processes.

The paper demonstrates multiplex base editing to convert TAG to TAA codons in 33 essential human genes and introduces a computational tool for recoding.

The paper identifies a single mutation, S43Y, that reduces transcription termination and RNA-dependent RNA polymerase activity in T7 RNA polymerase.