Author

Brian D. Ratnasinghe

Medical College of WisconsinORCID 0000-0002-6110-6445Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 2 Approach:statistical model· 2 Research Focus:variant effect prediction· 2 Research Focus:benchmarking· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1 Approach:simulation· 1

Frequent Co-Authors

Jessica B. WagenknechtiD· 2 shared Michael T. ZimmermanniD· 2 shared Neshatul HaqueiD· 2 shared Raul A. UrrutiaiD· 2 shared Angela MathisoniD· 1 shared Brian C. SmithiD· 1 shared Brian F. VolkmaniD· 1 shared Davin R. JenseniD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersGenetics

Jessica B. WagenknechtORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

GeneticsInternational Journal of Molecular SciencesPeer-reviewedFeb 14, 2026

A Multi-State Structural Genomics Approach Enables Large-Scale, Mechanistic, and Context-Specific Classification of ABCC6 Genetic Variants Implicated in Calcification Diseases

Jessica B. Wagenknecht, Neshatul Haque, Salomao D. Jorge…·Michael T. Zimmermann

The paper classifies ABCC6 genetic variants using structural genomics to identify pathogenic mechanisms and reclassify variants of uncertain significance.

2 citationstop 4%

humanDNA methylation

𝕏 PostBluesky

GenomicsComputational and Structural Biotechnology JournalPeer-reviewedJan 1, 2023

Beyond Structural Bioinformatics for Genomics with Dynamics Characterization of an Expanded KRAS Mutational Landscape

Brian D. Ratnasinghe, Neshatul Haque, Jessica B. Wagenknecht…·Michael T. Zimmermann

The paper uses molecular dynamics simulations to analyze 86 KRAS mutations, revealing mutation-specific conformations and functional insights not captured by current genomic tools.

10 citations

humanproteomics

𝕏 PostBluesky