Brian C. Smith

Acute BRD4 degradation and BD2 mutations de-repress bivalent developmental and neuronal genes in human stem cells and organoids, consistent with BRD4 recruitment by H3K14ac/H3K23ac and interaction with PRC1.6.

This study shows TAOK3 inhibition reduces cervical cancer invasion, increases paclitaxel sensitivity, and promotes anti-tumor immunity by altering the tumor microenvironment.

This paper classifies EHMT1 variants into structural, dynamic, and combined structural-dynamic categories using computational methods to improve variant interpretation for Kleefstra syndrome.

The paper uses molecular dynamics simulations to analyze 86 KRAS mutations, revealing mutation-specific conformations and functional insights not captured by current genomic tools.

The paper presents an online tool for semi-automated calculation of initial rates from continuous enzyme kinetic traces, improving accuracy and efficiency compared to manual methods.