The paper examines HLA variation in Neolithic European farming communities, finding increased HLA diversity due to admixture with western hunter-gatherers, but lower diversity compared to modern populations.

Genome biology · Feb 28, 2025Peer-reviewedGenetics

Neolithic introgression of IL23R-related protection against chronic inflammatory bowel diseases in modern Europeans

Ben Krause‐Kyora, Nicolas Antonio da Silva, Elif Kaplan, Daniel Kolbe, Sabine Schade-Lindig, Joachim Wahl, Carola Berszin, Michael Francken, Irina Görner, Kerstin Schierhold, Joachim Pechtl, Gisela Grupe, Johannes Müller, Inken Wohlers, Hauke Busch, , Stefan Schreiber

The paper traces the origin and spread of the IL23R variant rs11209026-A in Europe, linking its frequency changes to Neolithic agricultural practices and its protective role against inflammatory bowel diseases.

EBioMedicine · Feb 8, 2025Peer-reviewedEvolutionary Biology

Parallel paleogenomic transects reveal complex genetic history of early European farmers

Mark Lipson, Anna Szécsényi‐Nagy, Swapan Mallick, Annamária Pósa, Balázs Stégmár, Victoria Keerl, Nadin Rohland, Kristin Stewardson, Matthew Ferry, Megan Michel, Jonas Oppenheimer, Nasreen Broomandkhoshbacht, Éadaoin Harney, Susanne Nordenfelt, Bastien Llamas, , David Reich

The paper analyzes ancient DNA data from Neolithic and Chalcolithic Europe to study population dynamics and admixture patterns across different regions and time periods.

Nature · Nov 1, 2017Peer-reviewedGenetics