Daniel Kolbe

PD-L1-linked spatial decoupling of tumour-immune interactions in EBV-positive DLBCL

The paper investigates how PD-L1 genomic gains in EBV-positive DLBCL alter spatial tumour-immune interactions, revealing immune evasion through fibroblast exclusion, metabolic suppression, and T-cell exhaustion.

Rare genetic variants in the IIS/mTOR signalling pathway identified in exceptionally long-lived individuals show shared in vitro effects associated with lifespan across species

This study identifies rare genetic variants in the IIS/mTOR pathway in long-lived humans and shows they have shared functional effects on lifespan-related traits in mice.

Rare longevity-associated variants, including a reduced-function mutation in cGAS, identified in multigenerational long-lived families

The paper identifies rare longevity-associated variants, including a cGAS mutation, in long-lived families and shows they reduce inflammation and delay cellular senescence.

Admixture as a source for HLA variation in Neolithic European farming communities

The paper examines HLA variation in Neolithic European farming communities, finding increased HLA diversity due to admixture with western hunter-gatherers, but lower diversity compared to modern populations.

Neolithic introgression of IL23R-related protection against chronic inflammatory bowel diseases in modern Europeans

The paper traces the origin and spread of the IL23R variant rs11209026-A in Europe, linking its frequency changes to Neolithic agricultural practices and its protective role against inflammatory bowel diseases.