Henry C. Nguyen

This study compares two Pchlide binding modes in LPOR using simulations and mutagenesis, concluding that mode B, supported by new structural data, is thermodynamically favorable and challenges previous assumptions about the enzyme's mechanism.

The paper presents cryo-EM structures of human SIDT1 and SIDT2, revealing their dimeric architecture and demonstrating low-pH-dependent RNA binding and oligomerization.