Saaïd Safieddine

In utero adeno-associated virus (AAV)-mediated gene delivery targeting sensory and supporting cells in the embryonic mouse inner ear

This paper describes a protocol for in utero AAV-mediated gene delivery to the mouse inner ear, targeting sensory and supporting cells, and standardizes imaging procedures for reproducibility.

Otoferlin requires a free intravesicular C-terminal end for synaptic vesicle docking and fusion

This study shows that otoferlin's free C-terminal end is essential for synaptic vesicle docking and fusion in inner hair cells, as demonstrated by deafness and reduced exocytosis in a knock-in mouse model.