David Y. Barefield

Neprilysin mediated cleavage of phospholamban dysregulates SERCA in heart failure

This study shows that neprilysin cleavage of phospholamban disrupts SERCA function in heart failure, contributing to cardiac dysfunction.

Missense variants in the myosin binding domains of MYBPC3 and MYBPHL impair sarcomere incorporation

The paper investigates how missense variants in MYBPC3 and MYBPHL affect sarcomere incorporation by expressing variants in cardiomyocytes and assessing their localization and stoichiometric effects.

MYBPHL nonsense mutations have poor sarcomere binding, are degraded, and cause abnormal contraction

The paper investigates MYBPHL nonsense mutations, showing they impair sarcomere incorporation, lead to protein degradation, and cause contractile defects in cardiomyocytes.

The effects of conditional loss of myosin binding protein H-like on cardiac function.

This study investigates the effects of conditional MyBP-HL loss in mice, showing adult knock-down causes hypertrophy and atrial dysfunction, while conduction system-specific deletion leads to mild hypercontractility.

Enhancer and Promoter Usage in the Normal and Failed Human Heart

This study uses CAGE-seq to analyze promoter and enhancer usage in healthy and failed human hearts, identifying changes in gene regulation associated with heart failure.