Seby Louis Edassery

TRC051384, an Hsf1 activator, protects spiral ganglion neurons from noise-induced hearing loss by restoring proteasome function and preserving synapse density.

This study shows that neprilysin cleavage of phospholamban disrupts SERCA function in heart failure, contributing to cardiac dysfunction.

The paper identifies toxic transmembrane peptides that inhibit SERCA function in DCM, offering a new mechanism for calcium mishandling in heart failure.

This study shows calcium-activated contractility is not needed for sarcomere formation but is essential for cardiomyocyte maturation and response to mechanical cues, with nanopatterns aiding maturation in non-contractile cells.

This study identifies a soluble synaptic protein, 2{delta}-1, reduced in schizophrenia CSF, which enhances neuronal network dynamics and cognitive function when administered to a mouse model.

This study investigates the effects of intermittent nicotine self-administration in rats, finding increased nicotine seeking and neurobiological changes compared to continuous access.