This study examines cerebellar activity in PINK1 knockout rats during gait, finding hypoactivity in specific frequency bands linked to potential compensatory mechanisms for gait deficits.

Brain Communications · Jan 1, 2024Peer-reviewedNeuroscience

Cerebellar Activity in Hemi-Parkinsonian Rats during Volitional Gait and Freezing

Valerie DeAngelo, Arianna Gehan, Siya Paliwal, Katherine Ho, Justin D. Hilliard, Chia‐Han Chiang, Jonathan Viventi, George C. McConnell

This study examines cerebellar activity in hemi-parkinsonian rats during gait and freezing, finding hyperactivity at 21 days post-lesion and reduced activity during freezing.

Brain Communications · Jan 1, 2024Peer-reviewedNeuroscience

Dopaminergic but not Cholinergic Neurodegeneration is Correlated with Gait Disturbances in PINK1 Knockout Rats

Valerie DeAngelo, JD Hilliard, George C. McConnell

This study examines gait disturbances in PINK1 knockout rats, finding dopaminergic degeneration correlates with gait deficits while cholinergic loss does not.

Behavioural Brain Research · Sep 14, 2021Peer-reviewedNeuroscience