M. Yu. Obolenskaya

The paper compares gene expression in the first and second trimesters of healthy human pregnancy, identifying immune-related genes that change during placental development.

This study quantifies the effect of homocysteine on placental de novo purine biosynthesis using mass spectrometry and finds a dose-dependent decrease in newly formed purines.

The paper creates a gene expression database of preeclampsia-affected human placenta by processing and standardizing 33 datasets to improve analysis accuracy.

The paper describes the creation of a specialized database for microarray experiments and demonstrates its use with 32 placenta datasets under pre-eclampsia conditions.