The importance of stereochemistry in the disorder-order continuum of protein-protein interactions
Estella A. Newcombe, Amanda D. Due, Andrea Sottini, Steffie Elkjær, Frederik Friis Theisen, Catarina B. Fernandes, Lasse Staby, Elise Delaforge, Christian R. O. Bartling, Inna Brakti, Katrine Bugge, Benjamin Schuler, Karen Skriver, Johan Gotthardt Olsen, Birthe Brandt Kragelund
The paper investigates the role of stereochemistry in disordered protein-protein interactions, finding that chirality is inconsequential in fully disordered complexes but essential when folding and binding are coupled.
Nature · Nov 27, 2024Peer-reviewedBiophysics