Kalene R. Jasso

The paper investigates how physiological conditions like feeding, obesity, and circadian rhythm affect ciliary GPCR localization and cilia dynamics in the brain using MCHR1 and NPY2R as models.

The paper develops a strategy to fluorescently tag MCHR1, a ciliary GPCR, in vivo using CRISPR/Cas9, revealing its localization to neuronal cilia and identifying a new knockout line with altered synaptic strength.

This study shows that cilia loss in specific neurons affects locomotor responses to amphetamine differently in males and females.