Luke Zhu

A maternal germline mutator phenotype in a family affected by heritable colorectal cancer

The paper measures germline mutation rates in a family with MUTYH pathogenic variants, finding elevated C>A mutations in children of affected mothers but not fathers, suggesting maternal-specific mutator effects.

Identification of the molecular components of enhancer-mediated gene expression variation in multiple tissues regulating blood pressure

The paper identifies genes regulating blood pressure by analyzing enhancer variants and integrating epigenomic data with genotype-phenotype associations across multiple tissues.

mutyper: assigning and summarizing mutation types for analyzing germline mutation spectra

mutyper assigns mutation types to SNP data using ancestral genome estimates and computes mutation spectra for individuals and populations.

Genome-wide pleiotropy analysis identifies novel blood pressure variants and improves its polygenic risk scores

This study identifies novel blood pressure variants through pleiotropy analysis and improves polygenic risk scores for hypertension and cardiovascular disease.